Opportunity Information: Apply for W81XWH 20 OCRP CTRA
The CDMRP Ovarian Cancer Research Program (OCRP) Clinical Translational Research Award (CTRA) is a Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to move ovarian cancer research closer to real-world clinical impact by funding translational, patient-centered studies that are directly tied to a clinical trial. Rather than paying for the day-to-day operations of a trial, the award focuses on the correlative and translational science that can be layered onto a planned, ongoing, or completed clinical trial that is already supported by other funding. This structure is meant to help researchers extract deeper biological and clinical meaning from trial participation, patient samples, and trial data, ultimately improving how ovarian cancer is understood and treated.
At its core, this award supports correlative studies connected to clinical trials, meaning research that uses patient data and biospecimens to answer questions such as why some patients respond to a therapy and others do not, what biological pathways drive resistance, and which markers can predict outcomes. The program emphasizes translational work that targets high-impact problems or clear unmet needs in ovarian cancer, with a strong push toward practical outputs that can shape clinical decision-making. In addition to correlative science, projects that develop or refine clinical endpoints for trials are encouraged, which can include efforts to create, validate, or optimize outcome measures that make trials more informative, efficient, or patient-relevant.
A particularly encouraged focus area is precision medicine and computational approaches. The opportunity highlights the value of identifying individual tumor characteristics and predictive biomarkers, including work that uses advanced analytics, modeling, or bioinformatics to link molecular features to clinical outcomes. Importantly, the language also calls for approaches that work across diverse groups, signaling interest in research that does not only reflect narrow patient populations and that can improve care and outcomes broadly. In practice, competitive applications would likely propose robust strategies for integrating clinical data with molecular profiling, imaging, or other high-dimensional datasets to identify patient- or tumor-specific predictors of response, toxicity, recurrence risk, or survival.
The award comes with several key expectations that shape what applicants must be ready to deliver. First, the application must convincingly demonstrate that the research team has access to the necessary human subjects, specimens, or human-based resources. Because the work is trial-linked, this typically means showing that the relevant patient population is available, enrollment and consent pathways are feasible, and biospecimens or datasets can be obtained and used as proposed. Second, the proposal must include a detailed statistical analysis plan, including power calculations and sample size projections. This is meant to ensure that the study is not exploratory in a way that cannot yield interpretable results, and that the planned analyses have a realistic chance of producing meaningful, decision-informing conclusions.
There are also clear boundaries about what this funding will not support. The award is not intended to fund clinical trial operations, so applicants should not expect support for running the trial itself, such as routine participant visits, clinical care costs, or core trial management that would normally be covered by the primary trial sponsor. Additionally, preclinical animal studies are explicitly not allowed, reinforcing that this mechanism is centered on human-based translational research and clinically anchored questions rather than laboratory animal modeling.
From an administrative standpoint, this opportunity was released under Funding Opportunity Number W81XWH-20-OCRP-CTRA, categorized as discretionary funding, and offered through grant and cooperative agreement mechanisms under CFDA 12.420. Eligibility is listed as unrestricted, meaning a wide range of organizations may apply, subject to any additional eligibility notes in the full announcement. The posting indicates an expected five awards, and while an award ceiling is listed as 0 in the summary data, that typically reflects a posting artifact and would normally be clarified in the full program announcement or budget guidance. The opportunity was created on February 27, 2020, with an original closing date of July 30, 2020.
Overall, the CTRA is best understood as a mechanism for teams who already have a clinical trial context and want to answer the critical translational questions that trials often raise but cannot fully address without dedicated correlative funding. The program is geared toward well-justified, statistically rigorous, human-based studies that can identify biomarkers, validate computational or precision approaches, and improve how clinical trials measure and predict meaningful outcomes for people with ovarian cancer.Apply for W81XWH 20 OCRP CTRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "CDMRP Ovarian Cancer Research Program Clinical Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Feb 27, 2020.
- Applicants must submit their applications by Jul 30, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: CDMRP Ovarian Cancer Research Program (OCRP) Clinical Translational Research Award (CTRA)
What is the OCRP Clinical Translational Research Award (CTRA)?
The OCRP CTRA is a Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It supports translational, patient-centered ovarian cancer research that is directly tied to a clinical trial, with an emphasis on correlative and translational science that can help move findings toward real-world clinical impact.
What is the main purpose of this award?
The main purpose is to fund correlative and translational studies that can be layered onto a planned, ongoing, or completed clinical trial that already has separate support for trial operations. The goal is to extract deeper biological and clinical meaning from trial participation, patient samples, and trial data to improve how ovarian cancer is understood and treated.
Does the CTRA fund the clinical trial itself?
No. This award is not intended to pay for clinical trial operations or the day-to-day running of a trial. Routine participant visits, clinical care costs, and core trial management are examples of activities that would typically be covered by the primary trial sponsor rather than this mechanism.
What types of studies are considered “correlative” in this program?
Correlative studies are research efforts that use patient data and biospecimens connected to a clinical trial to answer questions such as why some patients respond to a therapy while others do not, what biological pathways drive resistance, and which markers can predict outcomes.
What kinds of research questions does the program emphasize?
The program emphasizes translational work that targets high-impact problems or clear unmet needs in ovarian cancer, with practical outputs that can shape clinical decision-making. Examples include identifying predictors of response or resistance and improving the interpretation of clinical trial results using patient-derived data.
Are projects focused on clinical endpoints allowed or encouraged?
Yes. Projects that develop, refine, validate, or optimize clinical endpoints for trials are encouraged. These efforts can focus on making trial outcome measures more informative, more efficient, or more patient-relevant.
Is precision medicine a priority area for the CTRA?
Yes. The opportunity particularly encourages precision medicine approaches, including identifying tumor characteristics and predictive biomarkers that can guide treatment or predict outcomes.
Are computational, modeling, or bioinformatics approaches supported?
Yes. The opportunity highlights computational approaches such as advanced analytics, modeling, or bioinformatics to connect molecular features to clinical outcomes, especially where high-dimensional datasets are integrated with clinical data.
Does the program indicate interest in research that applies across diverse patient groups?
Yes. The language calls for approaches that work across diverse groups, signaling interest in research that does not only reflect narrow patient populations and that can improve care and outcomes broadly.
What kinds of data or biospecimens might be used in a competitive project?
Based on the description, competitive projects would typically integrate clinical data with resources such as molecular profiling data, imaging, and other high-dimensional datasets, along with patient biospecimens and/or trial datasets as proposed.
What must applicants demonstrate about access to human subjects and resources?
Applicants must convincingly show access to the necessary human subjects, specimens, or human-based resources. Because the work is linked to a clinical trial, this generally involves demonstrating that the patient population is available, enrollment and consent pathways are feasible, and relevant biospecimens or datasets can be obtained and used as proposed.
Is a statistical analysis plan required?
Yes. The proposal must include a detailed statistical analysis plan, including power calculations and sample size projections, to support that the planned analyses are interpretable and have a realistic chance of producing meaningful conclusions.
Are exploratory projects allowed?
The opportunity emphasizes statistical rigor and requires power calculations and sample size projections, indicating that projects should be designed to yield interpretable, decision-informing results rather than being purely exploratory without a realistic path to meaningful conclusions.
Are preclinical animal studies allowed under this award?
No. Preclinical animal studies are explicitly not allowed. This mechanism is centered on human-based translational research anchored to clinically relevant questions.
What types of clinical trial contexts can this award be connected to?
The award can support correlative and translational science linked to a planned, ongoing, or completed clinical trial, as long as the clinical trial itself is already supported by other funding and the CTRA work is layered onto that trial context.
Who administers the program?
The funding opportunity is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Department of Defense CDMRP Ovarian Cancer Research Program (OCRP).
What is the Funding Opportunity Number for this award?
The Funding Opportunity Number listed is W81XWH-20-OCRP-CTRA.
What is the CFDA number associated with this opportunity?
The summary lists CFDA 12.420.
What funding mechanism types are associated with this opportunity?
The opportunity is offered through grant and cooperative agreement mechanisms.
What is the funding category for this opportunity?
It is categorized as discretionary funding.
Is eligibility restricted?
Eligibility is listed as unrestricted, meaning a wide range of organizations may apply, subject to any additional eligibility notes that would appear in the full announcement.
How many awards are expected?
The posting indicates an expected five awards.
What is the award ceiling?
The summary data lists an award ceiling of 0, which is described as likely a posting artifact. The actual ceiling would typically be clarified in the full program announcement or budget guidance.
When was this opportunity created and when did it close?
The opportunity was created on February 27, 2020, with an original closing date of July 30, 2020.
What is a simple way to describe the “fit” for this award?
This award is designed for teams that already have a clinical trial context and want dedicated support for the translational and correlative questions that arise from clinical trials, including biomarker discovery/validation, precision medicine analyses, computational approaches, and improved clinical endpoints in ovarian cancer.
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