Opportunity Information: Apply for W81XWH 20 SRP IDA
The DoD Scleroderma Idea Development Award (FY20 SRP IDA; Funding Opportunity Number W81XWH-20-SRP-IDA) is designed to push forward early-stage research ideas that could open up entirely new directions in scleroderma science or lead to meaningful improvements in patient care. The program is aimed at conceptually innovative, high-risk/high-reward projects rather than safe, incremental extensions of existing work. Applicants are expected to propose a clear, testable hypothesis backed by a solid scientific rationale and preliminary data, with the overall goal of generating high-impact findings related to the causes of scleroderma, how it progresses, and how outcomes and quality of life might be improved for patients.
A central requirement is that preliminary data must be included, but the program gives applicants flexibility on where those data come from. The preliminary evidence does not have to be generated within scleroderma specifically; it can come from the Principal Investigator's lab, collaborators named in the application, or even from relevant published literature, as long as it credibly supports the proposed hypothesis and approach. This structure is meant to encourage researchers to bring in tools, models, and insights from other fields when there is a strong argument that they can be translated to scleroderma in a meaningful way.
The award places a strong emphasis on innovation and impact. Competitive applications should demonstrate that the work could change how the field thinks about a problem, challenge an established model, or apply a novel perspective or method that creates a real chance for a leap forward. In contrast, projects framed as the next expected step in a research sequence are explicitly not the target of this mechanism. The impact expectation is broad but concrete: proposals should aim to advance understanding of disease mechanisms and progression and/or produce knowledge that can translate into better clinical care, management strategies, or patient quality of life.
Because this program sits within the Department of Defense Congressionally Directed Medical Research Programs framework, military relevance is not optional. Proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public, and military health relevance is considered during programmatic review. The announcement encourages applicants to build that relevance in practical ways, such as using military or Veteran populations, biospecimens, or databases; partnering with investigators at DoD military treatment facilities or laboratories or at VA medical centers and research labs; engaging military medical consultants or specialty leaders connected to the Surgeons General; or explaining how the resulting knowledge, products, or technologies could be used in a dual-use way that addresses a military need while also benefiting civilians. Applicants are also encouraged to connect their topic to military-relevant factors such as environmental exposures when appropriate.
The funding opportunity includes a specific pathway to support early-career faculty through the New Investigator Collaboration Option. Under this option, an established scleroderma researcher partners with a New Investigator who meets defined eligibility criteria. One PI serves as the Initiating PI and handles most submission-related administrative responsibilities, and this Initiating PI cannot be the New Investigator. The Partnering PI role is held by the New Investigator, and both PIs are expected to contribute substantially to the science and core application components, including the project narrative and statement of work. If selected for funding, each PI is named on an individual award within the recipient organization, reinforcing the intent to build the New Investigator's trajectory toward independence while maintaining strong guidance from an experienced collaborator.
Awards under this opportunity are issued as assistance agreements, meaning the government is supporting a public-purpose research effort rather than purchasing a product or service for direct government use. Depending on how much hands-on involvement the DoD anticipates during the project, the agreement may be structured as a grant (when no substantial involvement is expected) or as a cooperative agreement (when substantial involvement is expected, such as active collaboration or participation). The final choice of mechanism and start details are determined during award negotiations.
On the funding side, the anticipated direct cost cap for the full period of performance is up to $300,000 for a single-PI application, or up to $450,000 when using the New Investigator Collaboration Option. The program planned to allocate about $2.4 million total to support roughly four awards overall, anticipated as two standard Idea Development Awards and two awards under the collaboration option, although final funding decisions depend on federal fund availability, the volume of submissions, and outcomes of scientific and programmatic review. The opportunity was released July 17, 2020, with an original closing date of December 4, 2020, and awards were expected to be made no later than September 30, 2021. The funding was anticipated to use FY20 funds, with availability for use expiring September 30, 2026. Eligible applicants were listed as unrestricted (open to any entity type), subject to any additional eligibility clarifications in the full announcement.Apply for W81XWH 20 SRP IDA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Scleroderma, Idea Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jul 17, 2020.
- Applicants must submit their applications by Dec 04, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Scleroderma Idea Development Award (FY20 SRP IDA) - W81XWH-20-SRP-IDA
What is the DoD Scleroderma Idea Development Award (FY20 SRP IDA)?
The DoD Scleroderma Idea Development Award (FY20 SRP IDA; Funding Opportunity Number W81XWH-20-SRP-IDA) supports early-stage research ideas intended to open new directions in scleroderma science or lead to meaningful improvements in patient care. It is designed for conceptually innovative, high-risk/high-reward projects rather than incremental extensions of existing work.
What types of projects is this funding opportunity trying to support?
The program is aimed at projects that are innovative and potentially field-changing, such as work that challenges established models, reframes a problem, or applies novel perspectives, methods, tools, or models with a real chance of producing a leap forward in understanding or care.
What types of projects are not the target of this award?
Projects framed as the next expected step in a research sequence, or proposals that mainly extend existing work in a safe, incremental way, are explicitly not the target of this mechanism.
Do applicants need to propose a hypothesis?
Yes. Applicants are expected to propose a clear, testable hypothesis supported by a solid scientific rationale and preliminary data.
Is preliminary data required?
Yes. A central requirement is that preliminary data must be included in the application.
Does the preliminary data have to be generated specifically in scleroderma?
No. The preliminary evidence does not have to be generated within scleroderma specifically, as long as it credibly supports the proposed hypothesis and approach.
What sources of preliminary data are acceptable under this opportunity?
The opportunity allows flexibility in where preliminary data come from. Acceptable sources include the Principal Investigator's lab, collaborators named in the application, or relevant published literature, provided the evidence credibly supports the proposed hypothesis and approach.
Why does the program allow preliminary data from outside scleroderma?
This structure is meant to encourage researchers to bring in tools, models, and insights from other fields when there is a strong argument that they can be translated to scleroderma in a meaningful way.
What are the main goals or intended impact areas for funded work?
Proposals should aim to generate high-impact findings related to the causes of scleroderma, how it progresses, and how outcomes and quality of life might be improved. The impact expectation includes advancing understanding of disease mechanisms and progression and/or producing knowledge that can translate into better clinical care, management strategies, or patient quality of life.
Is military relevance required?
Yes. Because this program is within the Department of Defense Congressionally Directed Medical Research Programs framework, military relevance is not optional and is considered during programmatic review.
Who must the research be relevant to, from a military health perspective?
Proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public, and the military health relevance is part of programmatic review considerations.
How can applicants demonstrate military relevance in a practical way?
The announcement encourages practical approaches such as using military or Veteran populations, biospecimens, or databases; partnering with investigators at DoD military treatment facilities or laboratories or at VA medical centers and research labs; engaging military medical consultants or specialty leaders connected to the Surgeons General; or explaining how resulting knowledge, products, or technologies could be used in a dual-use way that addresses a military need while also benefiting civilians. Applicants are also encouraged to connect the topic to military-relevant factors such as environmental exposures when appropriate.
What is the New Investigator Collaboration Option?
The New Investigator Collaboration Option is a pathway within this opportunity intended to support early-career faculty by pairing an established scleroderma researcher with a New Investigator who meets defined eligibility criteria.
How does the PI structure work under the New Investigator Collaboration Option?
One PI serves as the Initiating PI and handles most submission-related administrative responsibilities, and this Initiating PI cannot be the New Investigator. The New Investigator serves as the Partnering PI.
Are both PIs expected to contribute meaningfully to the proposal under the collaboration option?
Yes. Both PIs are expected to contribute substantially to the science and to core application components, including the project narrative and statement of work.
If selected for funding under the collaboration option, how are awards issued to the PIs?
If selected for funding, each PI is named on an individual award within the recipient organization. This is intended to build the New Investigator's trajectory toward independence while maintaining strong guidance from an experienced collaborator.
What type of award instrument is used for this opportunity?
Awards are issued as assistance agreements, meaning the government is supporting a public-purpose research effort rather than purchasing a product or service for direct government use.
What is the difference between a grant and a cooperative agreement in this opportunity?
The agreement may be structured as a grant when no substantial involvement by the DoD is expected, or as a cooperative agreement when substantial involvement is expected (such as active collaboration or participation). The final choice is determined during award negotiations.
What is the direct cost cap for a single-PI application?
The anticipated direct cost cap for the full period of performance is up to $300,000 for a single-PI application.
What is the direct cost cap when using the New Investigator Collaboration Option?
The anticipated direct cost cap for the full period of performance is up to $450,000 when using the New Investigator Collaboration Option.
How much total funding was the program planning to allocate, and how many awards were expected?
The program planned to allocate about $2.4 million total to support roughly four awards overall, anticipated as two standard Idea Development Awards and two awards under the collaboration option. Final funding decisions depend on federal fund availability, the volume of submissions, and the outcomes of scientific and programmatic review.
When was this funding opportunity released and when did it close?
The opportunity was released on July 17, 2020, with an original closing date of December 4, 2020.
When were awards expected to be made?
Awards were expected to be made no later than September 30, 2021.
What fiscal year funds were anticipated, and when does availability expire?
The funding was anticipated to use FY20 funds, with availability for use expiring September 30, 2026.
Who was eligible to apply?
Eligible applicants were listed as unrestricted (open to any entity type), subject to any additional eligibility clarifications in the full announcement.
Does the opportunity specify how applications are reviewed?
The information provided indicates that both scientific and programmatic review influence outcomes, and that military health relevance is considered during programmatic review. It also notes that final funding decisions depend on federal fund availability and submission volume in addition to review outcomes.
What should an applicant emphasize to be competitive based on the description provided?
Competitive applications should emphasize conceptual innovation, high-risk/high-reward potential, a clear and testable hypothesis, credible preliminary data (including data from outside scleroderma when well-justified), and a compelling case for impact on understanding disease mechanisms/progression and/or translation to better clinical care, management, or quality of life. They should also clearly and credibly address required military relevance.
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