Role of Age-Associated Metabolic Changes in Alzheimer's Disease (AD) (R01) | PAR 17 031

Opportunity Information: Apply for PAR 17 031

The funding opportunity titled "Role of Age-Associated Metabolic Changes in Alzheimer's Disease (AD) (R01)" (Funding Opportunity Number PAR 17 031) is a discretionary research grant offered by the National Institutes of Health (NIH). It uses the R01 grant mechanism, which is NIH's standard award type for supporting mature, hypothesis-driven research projects that can produce substantial new knowledge. The focus of this announcement sits in the health research category (CFDA 93.866) and is aimed at expanding what is known about how aging-related shifts in metabolism at the molecular and cellular level may contribute to the onset and progression of Alzheimer's disease.

At the core, this FOA is looking for innovative experimental approaches that clarify the biological links between aging, metabolic change, and Alzheimer's disease. In practical terms, applicants are expected to propose rigorous studies that investigate how age-associated metabolic alterations influence key disease-relevant processes. The announcement emphasizes metabolism as a central theme, meaning projects might examine changes in energy production and use, nutrient sensing, mitochondrial function, oxidative stress biology, lipid and glucose metabolism, metabolic signaling pathways, or other metabolic features that change with age and could plausibly affect neuronal health, synaptic function, neuroinflammation, or other mechanisms involved in Alzheimer's pathology. The intent is not simply to describe correlations, but to push toward mechanistic understanding at the cellular and molecular scale, using experimental designs that can test causality and identify actionable targets for future therapeutic exploration.

The eligibility profile is broad, reflecting NIH's interest in attracting a wide range of scientific perspectives and institutional capacities. Eligible applicants include many types of U.S. governmental entities (state governments, county governments, city or township governments, special district governments), as well as independent school districts and public housing authorities/Indian housing authorities. Academic institutions are eligible across categories, including public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility is also extensive, including federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized tribal governments. The FOA also allows applications from nonprofits, whether they hold 501(c)(3) status or not (as long as they are not institutions of higher education), and it permits for-profit organizations other than small businesses, along with small businesses themselves. Beyond these standard categories, the FOA explicitly highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities, meaning foreign organizations can apply as well.

From an administrative perspective, the opportunity was created on 2016-10-25, and the original closing date listed in the source information is 2020-05-07. The funding instrument is a grant, and the activity category is health. The source record does not provide an award ceiling or the expected number of awards, which typically means interested applicants would need to consult the full FOA text or NIH program contacts for more detailed budget and award expectations, including any institute-specific limits, project period norms, or budget justification requirements that may apply under this R01 program announcement.

Overall, this FOA is best understood as a call for strong, experimentally grounded Alzheimer's disease research that treats age-related metabolic change as a central driver or modifier of disease biology. It aims to stimulate studies that can move the field beyond descriptive aging or AD observations and toward mechanistic insights that explain how metabolic aging intersects with Alzheimer's pathogenesis, potentially opening up clearer intervention points for prevention or treatment.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Role of Age-Associated Metabolic Changes in Alzheimer's Disease (AD) (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2016-10-25.
• Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 17 031

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