Opportunity Information: Apply for RFA NS 22 028
The BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs (eTeamBCP) (U01 Clinical Trials Optional) is an NIH cooperative agreement funding opportunity (RFA-NS-22-028) that supports early-stage, high-impact team science aimed at understanding how dynamic neural circuit activity drives behavior or operates within a well-defined neural system. It is a reissue of earlier announcements (RFA-NS-18-029 and RFA-NS-20-029) and is positioned as an exploratory on-ramp for groups planning to compete later for larger, longer, or more complex BRAIN Circuit Programs awards, such as the BRAIN TargetedBCP R01 or the multi-component Team-Research BRAIN Circuit Programs (U19). The emphasis is on ambitious, boundary-crossing research questions that are difficult or impossible to solve through a single-lab approach, with the expectation that the collaboration itself creates clear scientific synergy rather than simply assembling parallel efforts.
At its core, this FOA aims to enable large-scale analysis of neural circuits in context, meaning that circuit measurements should be made while an organism performs an ethologically relevant behavior or within a real-world, biologically meaningful functional setting. The opportunity strongly encourages proposals that integrate experimental approaches with computational and theoretical frameworks, so that new data streams are paired with modeling, analysis, and conceptual structure that can generalize beyond a single dataset. Teams are expected to bridge fields and levels of analysis by combining rich information about cell types with circuit function and connectivity, and then linking those circuit-level findings to rigorous, sophisticated behavioral analysis. The end goal is a mechanistic understanding of central nervous system circuits, not just descriptive mapping, and applicants are encouraged to use cutting-edge methods for large-scale recording, manipulation, and analysis across multiple CNS regions where appropriate.
Because this is a U01 cooperative agreement, NIH anticipates an active partnership role with awardees compared with a standard research project grant. While clinical trials are listed as optional, the scientific scope is centered on circuit mechanisms and behaviorally grounded systems neuroscience, with an exploratory flavor: building experimental capabilities, establishing team-integrated workflows, and developing theoretical or analytical frameworks that make larger-scale future efforts feasible and competitive. In practical terms, a strong application would typically show why the problem demands a coordinated team, how experimental and computational pieces will be truly integrated, and how the work could be transformative or enable major advances in understanding circuit-behavior relationships.
Eligibility is broad across U.S.-based organizational types, including state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (other than small businesses) and small businesses; public housing authorities/Indian housing authorities; and federally recognized tribal governments as well as other tribal organizations. The FOA also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign institutions (non-U.S. entities) are not eligible to apply directly; however, non-domestic components of U.S. organizations may participate, and foreign components are allowed as defined by the NIH Grants Policy Statement.
Key administrative details included in the listing are that the sponsoring agency is the National Institutes of Health, the funding instrument is a cooperative agreement (U01), and the opportunity falls under the broad activity areas of education, health, and related social services domains. The original closing date shown is April 25, 2023, and the CFDA assistance listing numbers associated with the opportunity include 93.173, 93.213, 93.242, 93.273, 93.279, 93.853, 93.865, 93.866, and 93.867. The announcement was created on March 2, 2022.Apply for RFA NS 22 028
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2022-03-02.
- Applicants must submit their applications by 2023-04-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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