Opportunity Information: Apply for CDC RFA PS21 2103

The Integrated Viral Hepatitis Surveillance and Prevention Funding for Health Departments opportunity (CDC RFA PS21-2103) is a CDC cooperative agreement designed to strengthen and better coordinate viral hepatitis surveillance and prevention work across U.S. states and large local jurisdictions. It focuses on building integrated programs that can both detect hepatitis trends quickly and translate that information into practical prevention and care strategies. The overarching goal is to help health departments move toward viral hepatitis elimination by improving how they plan for outbreaks, collect and use surveillance data, and connect people at highest risk to testing, treatment, and preventive services.

A central emphasis of the program is improving surveillance and readiness for response. Funded jurisdictions are expected to enhance outbreak planning and response capacity for viral hepatitis and to strengthen surveillance for acute hepatitis A, hepatitis B, and hepatitis C, along with chronic hepatitis C. In practice, this means improving the ability to identify new infections, detect clusters and outbreaks earlier, and ensure that case reporting and public health follow-up are complete and timely. The opportunity also calls for more comprehensive hepatitis B and C reporting, reflecting a priority on higher-quality data that can guide decisions, measure progress, and identify gaps in prevention and care.

Another major requirement is for recipients to develop a jurisdictional viral hepatitis elimination plan. This plan is meant to be more than a document; it is intended to drive coordinated action and stronger partnerships. Health departments are expected to increase stakeholder engagement in elimination planning, bringing together clinical providers, community organizations, correctional health partners, substance use services, and other key groups to align strategies. The program also prioritizes improving HBV and HCV testing efforts and expanding the number of healthcare providers trained to treat hepatitis B and hepatitis C, which supports longer-term capacity to diagnose and treat more people rather than relying on a small subset of specialists.

If additional funding is available, the NOFO describes expanded activities that can be supported. These include adding or enhancing surveillance for chronic hepatitis B and perinatal hepatitis C, which would help jurisdictions understand ongoing transmission patterns and improve prevention efforts for infants and families. It also includes increasing hepatitis B and C testing and referral to care in high-impact settings where risk and missed opportunities for diagnosis are often concentrated. Examples named in the opportunity include syringe services programs, substance use disorder treatment centers, correctional facilities, emergency departments, and sexually transmitted disease clinics. The intent is to place testing and linkage-to-care pathways in locations where people are more likely to be reached, especially those who may not have regular access to primary care.

The NOFO also highlights the importance of preventing viral hepatitis and other infections among people who inject drugs. Contingent on funding, jurisdictions can support efforts that expand access to prevention services for PWID, recognizing the overlapping risks for hepatitis and other infectious diseases and the value of providing practical, low-barrier services in community settings. Additionally, an optional component (also contingent on funding) would support improved access to prevention, diagnosis, and treatment for viral, bacterial, and fungal infections related to drug use in settings disproportionately affected by drug use. This optional element reflects a broader public health approach that addresses co-occurring infectious disease needs rather than treating hepatitis in isolation.

The expected outcomes of the program are framed around measurable improvements in public health capacity and service access. CDC anticipates stronger viral hepatitis surveillance systems, more meaningful stakeholder engagement tied to elimination planning, and improved access to prevention, diagnosis, and treatment services for populations most at risk. In short, the opportunity is structured to help health departments detect hepatitis more effectively, respond faster, plan collaboratively for elimination, and expand testing and care connections in the settings where they can have the greatest impact.

Administratively, this is a discretionary funding opportunity offered by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (NCHHSTP), using a cooperative agreement mechanism. Eligible applicants include state governments and local governments (counties, cities or townships) as well as special district governments. The opportunity was created on August 25, 2020, with an original application deadline of December 1, 2020 (applications due by 11:59 p.m. Eastern Time). CDC anticipated making 58 awards. The listing includes an award ceiling of 0, which typically indicates the ceiling was not specified in the summary data rather than implying no funding would be provided.

  • The Department of Health and Human Services, Centers for Disease Control - NCHHSTP in the health sector is offering a public funding opportunity titled "Integrated Viral Hepatitis Surveillance and Prevention Funding for Health Departments" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.270.
  • This funding opportunity was created on Aug 25, 2020.
  • Applicants must submit their applications by Dec 01, 2020 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 58 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments.
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